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BCRF Grantee Since


Donor Recognition

The Housewares Charity Foundation Award

Area(s) of Focus

William J. Gradishar, MD, FACP

Betsy Bramsen Professor of Breast Oncology
Director, Maggie Daley Center for Women’s Cancer Care
Robert H. Lurie Comprehensive Cancer Center
Feinberg School of Medicine
Northwestern University
Chicago, Illinois

Current Research

Basal-like tumors, which include those classified as triple negative, are clinically aggressive and lack targeted therapies. Drs. Cryns and Gradishar and their colleagues have shown that a cell stress protein called αB-crystallin contributes to the aggressive behavior of basal-like/triple-negative tumors. More recently, they developed new experimental models of basal-like breast cancer and have shown that αB-crystallin regulates the spread (metastasis) of breast cancer and have linked αB-crystallin to breast cancer stem cells, key regulators metastasis. During the next year of BCRF funding, the team will examine the mechanisms by which αB-crystallin promotes breast cancer stem cell survival and study whether αB-crystallin is co-expressed with breast cancer stem cell markers in breast tumors from patients. These studies could lead to new treatments for metastatic basal-like/triple-negative breast cancer.


William J. Gradishar is Betsy Bramsen Professor of Breast Oncology in the Division of Hematology and Medical Oncology at the Feinberg School Medicine at Northwestern University and a member of the Robert H. Lurie Comprehensive Cancer Center. He is Director of the Maggie Daley Center for Women’s Cancer Care. He has been Chair of the Annual Lynn Sage Breast Cancer Symposium since its inception. His research focuses on the development of novel therapeutics for the treatment of breast cancer.

A Fellow of the American College of Physicians, Dr. Gradishar is also a member of the American Association for Cancer Research, the American Federation for Clinical Research, and the Association of Subspecialty Professors. He is past chair of the Oncology Training Program Committee and Communications Committee of the American Society of Clinical Oncology (ASCO). He is Chair-elect of the ASCO Professional Development Committee and a member of ASCO’s Scientific Program Committee. He is a member of the Breast Cancer Core Committee and Co-Chair of the Developmental Therapeutics Working Group of the Eastern Cooperative Oncology Group, the Committee on Cancer of the American College of Surgeons, the National Comprehensive Cancer Network (NCCN) Breast Cancer Guidelines Panel, and the NCCN Breast Cancer Prevention Panel. He also serves as a consultant to the Oncology Drug Advisory Committee of the FDA. He has served on numerous study sections and is a member of the editorial board for the Journal of Clinical Oncology, Oncology, Clinical Breast Cancer, Journal Watch, European Journal of Clinical and Medical Oncology and Clinical Cancer Research.