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BCRF Grantee Since

2007

Donor Recognition

The ANN INC. Award

Nancy U. Lin, MD

Assistant Professor of Medicine, Harvard Medical School
Clinical Director, Breast Oncology Center
Dana-Farber Cancer Institute
Boston, Massachusetts

Current Research

Although significant advances have been made in the treatment of metastatic breast cancer, nearly all women with stage IV breast cancer will die of their disease. Drs. Nancy Lin and Eric Winer are actively pursuing new and promising alternatives for advanced breast cancer.  Over the past several years, with support from the BCRF they have completed multiple clinical trials to test new treatments for advanced breast cancer, including trials for patients with cancer that has metastasized (spread) to the brain.  Drs. Lin and Winer have also developed several new laboratory models for breast cancer brain metastases, which they are using to test new drug combinations to identify the most promising combinations for future clinical use. In addition, the investigators have expanded their efforts in metastatic breast cancer more broadly through the EMBRACE (Ending Metastatic Breast Cancer for Everyone) study, which collects blood, tumor tissue, and clinical data and will speed collaborations between the laboratory and clinic. These studies represent a major effort to better understand and treat patients with breast cancer and brain metastases, an area that until recently had been almost entirely neglected in drug development.

Bio

Dr. Lin is a medical oncologist at Dana-Farber Cancer Institute (DFCI) and Assistant Professor of Medicine at Harvard Medical School. Dr. Lin received her medical degree at Harvard Medical School and subsequently completed her residency in Internal Medicine at Brigham & Women's Hospital and a fellowship in Hematology/Oncology at Dana-Farber/Partners Cancer Care. Since 2012, she has served as Clinical Director of the Breast Oncology Center at DFCI.

Dr. Lin's focus is on developing novel targeted therapies for patients with advanced breast cancer and exploring mechanisms of drug resistance, with a particular interest in patients with breast cancer that has metastasized to the brain. Dr. Lin is leading multiple ongoing and planned clinical trials evaluating a variety of targeted approaches in patients with metastatic breast cancer. Her work is highly collaborative and involves close working relationships with clinicians, laboratory investigators, and patient advocates. Dr. Lin's honors and awards include a Young Investigator Award and Career Development Award from the American Society of Clinical Oncology. She is a member of the Massachusetts Medical Society, American Society of Clinical Oncology, Alliance for Clinical Trials in Oncology, and Translational Breast Cancer Research Consortium.

Co-Investigators