Professor, Department of Epidemiology
Mailman School of Public Health
New York, New York
Family history is a known risk factor for breast cancer, but few breast cancers within families can be explained by known gene mutations, such as mutations in the BRCA1 and BRCA2 genes. Drs. Santella and Terry are pursuing multiple approaches to better understand breast cancer risk in high-risk families. Their studies are based in the Breast Cancer Family Registry (BCFR), a cohort of families at high risk for breast and ovarian cancer, and in LEGACY, a cohort of young girls from these high risk families as well as from average risk families. In the coming year they will carry out pilot studies in women from the BCFR study using biomarkers of exposure to polycyclic aromatic hydrocarbons (PAH), one of the most prevalent environmental pollutants known to cause cancer by damaging DNA. They hope to determine whether exposure to these compounds is associated with breast cancer risk and continue to expand their ongoing studies of PAH exposure in the young girls enrolled in the LEGACY study. Utlimately, their goal is to improve risk prediction and modification by incorporating biomarker data into current risk models.
Mary Beth Terry, PhD, is a Professor of Epidemiology at Columbia University’s Mailman School of Public Health. She focuses her research on breast cancer and in the molecular epidemiology and life-course methods of the disease, in particular. She is a cancer epidemiologist with over 15 years of leading studies of breast cancer etiology specifically focused on the role genetics, epigenetics, and other biomarkers play in modifying the effects of environmental exposures. Dr. Terry currently leads four NIH grants through the National Cancer Institute and the National Institute for Environmental Health Sciences that focus on following cancer risk within family-based cohorts. Her more recent work studying biomarkers, which can be modified throughout life, supports the assertion that selected markers of DNA methylation and other biomarkers are associated with breast cancer risk even within high risk families. Understanding whether biomarkers can help explain risk in higher risk women is important, as only a minority of women with a family history of cancer carry the BRCA1 or BRCA2 mutation. Her work also focuses on measuring risk factors for mammographic density, a strong intermediate marker of breast cancer. In addition to her doctorate in epidemiology from Columbia University, Dr. Terry has a Master's degree in economics and previously worked as an econometrician and program evaluator for a number of government-sponsored programs. Dr. Terry teaches introductory and advanced epidemiologic methods at the Mailman School of Public Health.