Kathleen & Stanley Glaser Professor of Medicine
Deputy Director, Sylvester Comprehensive Cancer Center
University of Miami
Despite great strides in treatment for localized breast cancer, metastatic breast cancer remains an overwhelmingly lethal disease. Most breast cancer research has focused on breast cancer cells themselves in order to identify mechanisms of disease progression. It is now widely appreciated that changes in the behavior and characteristics of non-cancer cells of the breast, either caused by the presence of breast cancer or influenced by pre-existing risk factors such as obesity and depression, contribute directly to breast cancer progression and malignant spread. Through support from BCRF, Dr. Lippman and his team have made progress toward identifying contributing host/environmental factors by developing models to study the role of specific genes in breast cancer metastasis. The cominbation of a receptor called RAGE and its binding partner (S100A8/A9) has been shown to be overexpressed in breast cancer and Dr. Lippman’s group identified S100A8 as a potential biomarker for risk of metastsis. They are now studying the specific contribution of RAGE and S100A8/A9 to breast cancer metastasis, while continuing an ongoing study to identify factors present in the circulation of patients with metastatic breast cancer that may be critical to the metastatic process. These studies involve the analysis of patients samples to identify myeloid cell populations, cytokines and inflammatory markers, and other circulating determinants of disease progression, in particular CAFs (Cancer Associated Fibroblasts) that are specifically associated with breast cancer metastasis
Marc E. Lippman, MD, MACP FRCP is the Kathleen and Stanley Glaser Professor of Medicine at the University of Miami Leonard School of Medicine, and was Chairman of the Department of Medicine from May 2007 to May 2012. He is currently Deputy Director of the Sylvester Comprehensive Cancer Center. Previously Dr. Lippman was the John G. Searle Professor and Chair of Internal Medicine at the University of Michigan. From 1988 through 1999 he was Professor of Medicine and Pharmacology and Chair, Department of Oncology, at Georgetown University in Washington, DC, and served as Director of the Lombardi Cancer Center. Dr. Lippman served as Head of the Medical Breast Cancer Section, Medicine Branch, at the NIH. He completed a Fellowship in Endocrinology at Yale Medical School from 1973-1974. He was Clinical Associate at the NCI from 1970-1971 and Clinical Associate at the Laboratory of Biochemistry of the NCI. From 1970-1988 he served as an Officer and Medical Director of the United States Public Health Service. Dr. Lippman completed his residency on the Osler Medical Service, John Hopkins University Hospital from 1968-1970. He has received numerous awards including Clinical Investigator Award, American Federation for Clinical Research in 1985; Transatlantic Medal and Lecture, British Endocrine Societies, 1989; the Astwood Award, Endocrine Society, 1991; the Bernard Fisher Award, University of Pittsburgh in 1991; the AACR Rosenthal Award in April 1994, and the Brinker Award for Basic Science of the Komen Foundation in 1994.