Kathleen & Stanley Glaser Professor
Chairman, Department of Medicine
Miller School of Medicine, University of Miami
Women undergoing treatment for breast cancer may suffer from periodic or chronic depression for a number of reasons. Depression not only affects overall quality of life but has effects on the body’s immune system as well. Work by Dr. Lippman has shown that depression increases certain immunosuppressive factors that promote tumor progression, suggesting that regulating systemic inflammation may be of potential therapeutic interest. During the course of his BCRF-funded research, Dr. Lippman has identified key players that may be therapeutic targets to inhibit breast tumor growth and metastasis. In the coming year he will continue his work in understanding the biological mechanisms linking systemic inflammation, depression and breast cancer progression. He is currently proposing a clinical study to explore whether successful treatment of depression in women with breast cancer may be an approach to modulate systemic inflammation and reduce the risk of metastasis. Understanding how a woman’s emotional state can influence cancer behavior may provide unique opportunities to intervene and control the metastatic process.
Marc E. Lippman, MD, MACP FRCP is the Kathleen and Stanley Glaser Professor of Medicine at the University of Miami Leonard School of Medicine, and was Chairman of the Department of Medicine from May 2007 to May 2012. He is currently Deputy Director of the Sylvester Comprehensive Cancer Center. Previously Dr. Lippman was the John G. Searle Professor and Chair of Internal Medicine at the University of Michigan. From 1988 through 1999 he was Professor of Medicine and Pharmacology and Chair, Department of Oncology, at Georgetown University in Washington, DC, and served as Director of the Lombardi Cancer Center. Dr. Lippman served as Head of the Medical Breast Cancer Section, Medicine Branch, at the NIH. He completed a Fellowship in Endocrinology at Yale Medical School from 1973-1974. He was Clinical Associate at the NCI from 1970-1971 and Clinical Associate at the Laboratory of Biochemistry of the NCI. From 1970-1988 he served as an Officer and Medical Director of the United States Public Health Service. Dr. Lippman completed his residency on the Osler Medical Service, John Hopkins University Hospital from 1968-1970. He has received numerous awards including Clinical Investigator Award, American Federation for Clinical Research in 1985; Transatlantic Medal and Lecture, British Endocrine Societies, 1989; the Astwood Award, Endocrine Society, 1991; the Bernard Fisher Award, University of Pittsburgh in 1991; the AACR Rosenthal Award in April 1994, and the Brinker Award for Basic Science of the Komen Foundation in 1994.