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BCRF Grantee Since


Donor Recognition

The Hamptons Paddle & Party for Pink Award

Area(s) of Focus

Lewis A. Chodosh, MD, PhD

J. Samuel Staub Professor
Chair, Department of Cancer Biology
Abramson Family Cancer Research Institute
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania

Current Research

The principal cause of death from breast cancer is tumor recurrence, which can occur 20 years or more after treatment of the original breast cancer. Growing evidence suggests that recurrent breast cancers are fundamentally different from the primary breast cancers from which they arose. Consequently, drugs that are effective against primary tumors may be ineffectual against dormant tumor cells that survive therapy, or against tumors that have recurred following therapy. In order to understand the mechanisms that underlie this tendency of breast cancers to progress to more aggressive states, the Chodosh laboratory has developed novel experimental models for human breast cancer. These models are being used to elucidate the mechanisms that allow breast cancer cells to survive therapy and recur years after treatment of the originally diagnosed breast cancer. By identifying the specific pathways and genes by which breast cancers recur, these studies have the potential to provide critical new drug targets essential for the development of more effective therapies and to dramatically alter the treatment options for millions of breast cancer survivors.


Dr. Lewis A. Chodosh is a physician-scientist who received a BS in Molecular Biophysics and Biochemistry from Yale University, and MD from Harvard Medical School, and a PhD. in Biochemistry from M.I.T. in the laboratory of Dr. Phillip Sharp.  He performed his clinical training in Internal Medicine and Endocrinology at the Massachusetts General Hospital, after which he was a postdoctoral research fellow with Dr. Philip Leder at Harvard Medical School.  Dr. Chodosh joined the faculty of the University of Pennsylvania in 1994, where he is currently a Professor in the Departments of Cancer Biology, Cell & Developmental Biology, and Medicine.  Dr. Chodosh serves as Chairman of the Department of Cancer Biology, Associate Director for Basic Science of the Abramson Cancer Center, and Director of Cancer Genetics for the Abramson Family Cancer Research Institute at the University of Pennsylvania.  Dr. Chodosh also serves as Editor-in-Chief of Breast Cancer Research and is on the scientific advisory board for the Harvard Nurses' Health Studies I and II.  His research focuses on genetic, genomic and molecular approaches to understanding breast cancer susceptibility and pathogenesis.