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BCRF Grantee Since

2003

Donor Recognition

The Hamptons Paddle & Party for Pink Award

Area(s) of Focus

Lewis A. Chodosh, MD, PhD

J. Samuel Staub Professor
Chair, Department of Cancer Biology
Abramson Family Cancer Research Institute
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania

Current Research

Research has clearly demonstrated that the susceptibility of the mammary gland to cancer is influenced by normal developmental events such as puberty, pregnancy, and parity (number of births). The Chodosh laboratory has developed a collection of unique experimental models of human breast cancer in order to study how these processes modulate breast cancer risk and to learn why some breast cancers progress to more aggressive states. During the past year they have used these models to test a new drug that targets the prolactin receptor pathway, a critical hormone-driven pathway in breast cells, which has been implicated in development of breast cancer. In the coming year, they will continue these studies to understand the effects of the drugs at a molecular and a cellular level and to determine how to leverage these findings to develop better treatments for breast cancer. In addition to these efforts, the Chodosh laboratory has also developed a computational tool termed EPS that can detect whether individual human breast cancers have activated a specific signaling pathway that may be driving the cancer growth. This may help to match patients with targeted drugs that are most likely to be effective against their cancer. In the coming year, they will continue to refine this tool with the hopes of determining whether it might eventually be useful for guiding treatment decisions in women with breast cancer.

Bio

Dr. Lewis A. Chodosh is a physician-scientist who received a BS in Molecular Biophysics and Biochemistry from Yale University, and MD from Harvard Medical School, and a PhD. in Biochemistry from M.I.T. in the laboratory of Dr. Phillip Sharp.  He performed his clinical training in Internal Medicine and Endocrinology at the Massachusetts General Hospital, after which he was a postdoctoral research fellow with Dr. Philip Leder at Harvard Medical School.  Dr. Chodosh joined the faculty of the University of Pennsylvania in 1994, where he is currently a Professor in the Departments of Cancer Biology, Cell & Developmental Biology, and Medicine.  Dr. Chodosh serves as Chairman of the Department of Cancer Biology, Associate Director for Basic Science of the Abramson Cancer Center, and Director of Cancer Genetics for the Abramson Family Cancer Research Institute at the University of Pennsylvania.  Dr. Chodosh also serves as Editor-in-Chief of Breast Cancer Research and is on the scientific advisory board for the Harvard Nurses' Health Studies I and II.  His research focuses on genetic, genomic and molecular approaches to understanding breast cancer susceptibility and pathogenesis.