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BCRF Grantee Since

2005

Donor Recognition

The Estée Lauder Companies Brands Award in Memory of Evelyn H. Lauder

Area(s) of Focus

Jill Bargonetti, PhD

Chair, Molecular, Cellular and Developmental
PhD Subprogram in Biology
CUNY Graduate Center
Professor, Department of Biological Sciences
Hunter College
New York, New York

Current Research

Dr. Bargonetti’s team focuses on two of the most critical drivers of breast cancer, namely MDM2 and mutant p53 (mtp53). Under normal conditions, these proteins prevent damaged cells from dividing. They often become dysregulated in cancer, however and promoted tumor growth. Dr. Bargonetti and colleagues are determining the protein targets of MDM2 and mutant p53 using their novel breast cancer cell lines derived from both ER+ and triple negative breast cancers. They are currently focusing on the new protein targets and testing them for their ability to stop cancer cells from replicating and spreading.

Bio

Dr. Bargonetti began at Hunter College as an Assistant Professor in 1994 and is currently a Full Professor and the Chair of the Molecular, Cellular and Developmental PhD Subprogram in Biology at the CUNY Graduate Center. Professor Bargonetti has carried out extensive research on the wild-type p53 protein (which assists in the suppression of tumor cells) and oncogenic mutant p53 (which is a tumor promoter). She is also a leader in the field of MDM2 research concerning its involvement in the promotion of breast cancer through both chromatin-based inhibition of the p53 pathway and cell growth promotion through p53-independent mechanisms. She was a member of the National Cancer Policy Board from 2002 until 2005 (a board of the Institution of Medicine and National Research Council of the National Academies) and currently serves on the NIH Tumor Cell Biology study section.