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BCRF Grantee Since


Donor Recognition

The Estée Lauder Companies Brands Award in Honor of Elizabeth Hurley

Area(s) of Focus

Ian E. Smith, MD, FRCP, FRCPE

Professor of Cancer Medicine
The Royal Marsden Hospital and Institute of Cancer Research
Head of the Breast Unit, The Royal Marsden Hospital Institute of Cancer Research
London UK

Current Research

Estrogen receptor-positive (ER+) breast cancer makes up more than two-thirds of all breast cancer cases, particularly those that occur after menopause. While a variety of successful anti-estrogen drugs are available to treat post-menopausal breast cancer, there are fewer treatment options for younger women with ER+ breast cancer. Drs. Smith and Dowsett are using new technologies to find better treatments for ER+ breast cancer in younger women in the UK, the US and Vietnam. In the course of this work, they have found changes in specific genes that occur at different times during the menstrual cycle of breast cancer patients. They believe that this information can be used to predict the benefit that individual patients may expect from subsequent anti-estrogen therapy.


Ian E. Smith, MD, FRCP, FRCPE, is Professor of Cancer Medicine at The Royal Marsden Hospital and Institute of Cancer Research, London, and Head of the Breast Unit at The Royal Marsden Hospital. His principal clinical research interests have been in breast cancer, lung cancer and in new drug development. He was involved in the early clinical development of several anticancer drugs that have subsequently proved effective, including carboplatin and letrozole. In the last decade he has become increasingly involved in neoadjuvant therapies as a research approach towards individualizing treatment for breast cancer. He is currently Principal Investigator for several international multicenter breast cancer trials involving targeted therapies and aromatase inhibitors. He publishes and lectures extensively. He was awarded the Susan G. Komen for the Cure Brinker Award for Scientific Distinction in 2009.

Professor Smith was first chairman of the UK Breast Trials Intergroup and chairman of the British Breast Group, Scientific Chairman of the Breast Section of 2012 ESMO, and has also chaired several national professional bodies including the Association of Cancer Physicians, the Royal College of Physicians Specialist Advisory Committee for Medical Oncology, and the NCRI Lung Cancer Clinical Studies Group. He is currently Co –Chairman of the ASCO Clinical Guidelines Group for Chemotherapy in Metastatic Breast Cancer, and has just been appointed the first Chair of the newly formed UK Breast Cancer Clinical Reference Group. He is a patron of Breast Cancer Care, the largest UK breast charity for patient support.

Latest from Ian E. Smith


FMedSci, PhD