Department of Cancer Prevention and Control
Roswell Park Cancer Institute
Buffalo, New York
Because all cancers originate from mutations in DNA, research on racial differences at the DNA level will likely increase our understanding of breast cancer biology, particularly for more aggressive triple negative breast cancers, which occur more frequently in African Americans compared to Caucasians. Drs. Hong and Ambrosone are comparing DNA mutations in triple negative breast tumors from African American women to those of Caucasian women. There are very few studies that have examined the differences in breast cancer tumor mutations between these populations, and these studies will provide important insights into the biological mechanisms that may help explain breast cancer disparities and open up new areas of research.
Dr. Chi-Chen Hong is an Assistant Member in the Department of Cancer Prevention and Control within the Division of Cancer Prevention and Population Sciences. Dr. Hong's research is focused on breast cancer etiology, survivorship, and prognosis. Specifically, her interests are on the influence of lifestyle, comorbidity, genetics, and immune factors. She has an ongoing prospective cohort study of early stage breast cancer patients to examine issues in breast cancer survivorship, and with colleagues at the Rutgers Cancer Institute of New Jersey and Rutgers University is principal investigator of a study examining the role of obesity and related comorbidities, including asthma and type 2 diabetes, and their management on quality-of-life and breast cancer survival outcomes among African American women, and to elucidate key pathways mediating these associations.