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BCRF Grantee Since

2013

Area(s) of Focus

Angela R. Bradbury, MD

Conquer Cancer Foundation of ASCO
Assistant Professor, Department of Medicine
Cancer Risk Evaluation Program
University of Pennsylvania School of Medicine
Philadelphia, PA

Current Research

Multiplex testing for inherited susceptibility of cancer is a new form of genetic testing that uses a single specimen of blood to test for many different gene mutations, rather than just one or two. The emergence of multiplex testing and whole exome/genome sequencing has presented new challenges in issues of informed consent and genetic counseling for cancer susceptibility testing. The goal of Dr. Bradbury’s Conquer Cancer Foundation study, conducted with support from BCRF, is to evaluate whether research participants choose to receive the results of genetic testing for breast cancer susceptibility The project is designed to evaluate the short and long-term benefits and risks of offering these results by evaluating patients’ understanding of and reaction to the information provided by the genetic screening. Dr. Bradbury and her team will assess responses to determine what factors affect the decision to receive genetic testing results and what factors affect outcomes after the participants receive their results. In the last year, they initiated a pilot study that utilizes a new genetic counseling model. The study is ongoing and is in the data collection and analysis phase with two manuscripts in preparation. The researchers continue to refine the counseling and informed consent models as data are analyzed, and they will begin a larger longitudinal study in the coming year. These efforts may lead to new guidelines and recommendation for healthcare providers offering multiplex genetic screening and counseling in high-risk populations.

Bio

Dr. Angela Bradbury is an Assistant Professor in the Department of Medicine, Division of Hematology-Oncology at the University of Pennsylvania. She is a physician in the Cancer Risk Evaluation Program and also has a secondary appointment in the Department of Medical Ethics and Health Policy. Dr. Bradbury is a medical oncologist with specialized training in breast oncology, clinical cancer genetics and medical ethics. She has been developing and leading translational genetic research focused on the clinical implementation of genetic medicine to promote the health of individuals, families and communities since 2003. This includes studies evaluating delivery and dissemination of genetic services, communication of genetic information in clinical care and within families and the impact of early communication of genetic risk in adolescent girls. She is the recipient of an American Cancer Society Mentored Research Scholar Award and American Society of Clinical Oncology (ASCO) Young Investigator Award and more recently multiple National Institutes of Health grants evaluating early determinants of breast cancer risk and psychosocial adjustment in teen girls (R01 CA138819 Daly/Bradbury) and novel cancer genetic delivery models to facilitate dissemination and implementation of cancer genetics (R01 CA160847-01A1 /R21CA164121-02).