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BCRF Grantee Since


Donor Recognition

The Bloomingdale's Award

Area(s) of Focus

Andrew J. Dannenberg, MD

Henry R. Erle, MD-Roberts Family Professor of Medicine
Weill Cornell Medical College
Director of Cancer Prevention,
New York Presbyterian Hospital-Cornell
New York, New York

Current Research

Obesity is a risk factor for the development of hormone receptor-positive breast cancer after menopause. In addition to increasing risk, obesity has been associated with poor outcomes for breast cancer patients. Chronic inflammation increases the risk of developing numerous other malignancies, and Dr. Dannenberg’s laboratory was the first to link obesity with breast inflammation and the development and progression of breast cancer. The focus of his BCRF research is to determine the molecular mechanisms of this relationship with the goal of reducing breast cancer risk with targeted interventions. During the past year, his laboratory has shown that menopause also influences breast inflammation and is currently pursuing studies to explain this effect. Importantly, this work led to the discovery that a subset of healthy weight women have occult breast inflammation with associated insulin resistance and possibly an increased risk of breast cancer. Given these findings, Dr. Dannenberg’s current project is focused on defining the mechanisms by which obesity-related inflammation impacts breast cancer and developing a blood test to non-invasively determine if a woman has occult breast inflammation. This is important because it is impractical to carry out biopsies to make this diagnosis. To augment this work, his team is utilizing laboratory models to determine whether behavioral (calorie restriction, exercise) or pharmacological approaches can reverse obesity-related inflammation.


Andrew J. Dannenberg, MD is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College. He is also Director of Cancer Prevention at New York Presbyterian Hospital-Cornell. Dr. Dannenberg received his medical degree from Washington University in St. Louis and served as a medical resident and fellow at The New York Hospital-Cornell Medical Center. He has authored more than 150 scientific articles, as well as edited several books and journals. In 2011, Dr. Dannenberg was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians (AAP), the American Society for Clinical Investigation (ASCI), and the American Association for Cancer Research.

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