Research on
Inherited Susceptibility to Breast Cancer addresses the "inheritability" of cancer. BCRF investigators have elucidated what we know about the mutations in the BRCA1 and BRCA2 genes, and they have identified additional inheritable mutations. They have created the most comprehensive database of breast cancer genes ever assembled. In addition, they are studying the varied forms of breast cancer that occur in different populations. Furthermore, they have identified evolutionary protection against diseases, such as malaria, that seem to bring on the development of aggressive forms of breast cancer. Ultimately, BCRF-funded investigators intend to be able to use genetic information of individuals to help them prevent the development of breast cancer, as well as shed light on what physicians can do to prevent the disease's onset.
Grantees in 2012-2013 examining Inherited Susceptibility to Breast Cancer are:
Ross Berkowitz, MD, Ursula Matulonis, MD, and Zhigang Charles Wang, MD, PhD
Joan S. Brugge, PhD
Fergus J. Couch, PhD
Susan M. Domchek, MD and Robert H. Vonderheide, MD, D.Phil
Charis Eng, MD, PhD, FACP
Judy E. Garber, MD, MPH
J. Dirk Iglehart, MD, Andrea Richardson, MD, PhD, and Zhigang Charles Wang, MD, PhD
Tan A. Ince, MD, PhD
Mary-Claire King, PhD, Ephrat Levy-Lahad, MD, and Moien Kanaan, PhD
Mary-Claire King, PhD and Joan H. Marks, MS
Charlotte Kuperwasser, PhD
Joshua LaBaer, PhD
Arnold J. Levine, PhD and Kim Hirshfield, MD, PhD
Marc E. Lippman, MD
David M. Livingston, MD
Richard R. Love, MD
Sofia Merajver, MD, PhD
Katherine L. Nathanson, MD
Kenneth Offit, MD, MPH and Mark Robson, MD
Olufunmilayo I. Olopade, MD
C. Barbara A. Parker, MD
Michael F. Press, MD, PhD
Gad Rennert, MD, PhD
Nadine M. Tung, MD and Stuart J. Schnitt, MD
