The Breast Cancer Research Foundation Medical Symposium held at the Waldorf=Astoria, NYC on Wednesday, October 29, 2008

Evelyn H. Lauder
Founder and Chairman, The Breast Cancer Research Foundation

Panel Moderator:

Larry Norton, MD
Chairman, BCRF Executive Board of Scientific Advisors
Deputy Physician-in-Chief of Memorial Hospital
Director of Breast Cancer Programs, Memorial Sloan-Kettering Cancer Center, New York, NY

Panelists:

Robert A. Weinberg, PhD
Founding Member, Whitehead Institute for Biomedical Research, Cambridge, MA

Charlotte Kuperwasser, PhD
Assistant Professor, Departments of Anatomy & Cellular Biology, Tufts University School of Medicine, Molecular Oncology Research Institute (MORI), Boston, MA

Michael F. Clarke, MD
Professor of Internal Medicine; Karel and Abice Beekhuis Endowed Professor; Deputy Director of the Stem and Regenerative Medicine Institute. Stanford University, Palo Alto, CA

Hope S. Rugo, MD
Clinical Professor of Medicine; Director, Breast Oncology Clinical Trials Program, University of California San Francisco Comprehensive Cancer Center

Joan S. Brugge, PhD
Chair, Department of Cell Biology, Harvard Medical School, Boston, MA



Q&A Topics and Discussion

Are vitamin supplements recommended?
Response by:
Robert A. Weinberg, PhD (Panelist)
Joan S. Brugge, PhD (Panelist)
Introduction and comments: Larry Norton, MD (Moderator)

Continued discussion on impact of lifestyle factors on health (vitamins, diet, exercise)
Response by:
Charlotte Kuperwasser, PhD (Panelist)
Walter C. Willett, PhD, Dr.PH (from the audience)
Chair, Department of Nutrition; Professor of Epidemiology and Nutrition; Professor of Medicine, Harvard Medical School, Harvard School of Public Health, Boston, MA
Comments by: Larry Norton, MD (Moderator)

Continued discussion on impact of lifestyle factors on health (vitamins, diet, exercise)
Response by:
Peter Greenwald, MD, Dr.PH (from the audience)
Director, National Cancer Institute, Division of Cancer Prevention and Control, National Institutes of Health, Bethesda, Maryland
Hope S. Rugo (Panelist)
Comments by: Larry Norton, MD (Moderator)

How much vitamin D / Is D3 the best form to take?
Response by:
Walter C. Willett, PhD, Dr.PH (from the audience)
Chair, Department of Nutrition; Professor of Epidemiology and Nutrition; Professor of Medicine, Harvard Medical School, Harvard School of Public Health, Boston, MA
Pamela J. Goodwin, MD, MSc, FRCP(C) (from the audience)
Scientist, Samuel Lunenfeld Research Institute; Marvelle Koffler Chair in Breast Research; Professor of Medicine, University of Toronto; Mount Sinai Hospital, Toronto, Ontario, Canada
Comments by: Larry Norton, MD (Moderator)

Research has led to more sophisticated understanding of cancer
Response by: Larry Norton, MD (Moderator)

Interaction between genes and the environment
Response by: Robert A. Weinberg, PhD (Panelist)

Defining stem cells, their properties and their role in cancer
Response by:
Michael F. Clarke, MD (Panelist)
Robert A. Weinberg, PhD (Panelist)
Introduction by: Larry Norton, MD (Moderator)

BRCA genes/lifestyle factors and PARP inhibitors
Response by:
Mary-Claire King, PhD (from the audience)
American Cancer Society Professor, Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA
Alan Ashworth, BSc, PhD, FRS (from the audience)
Professor, Molecular Biology and Director, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK

What effect does a mastectomy have on a cancerous stem cell?
Response by:
Robert A. Weinberg, PhD (Panelist)
Michael F. Clarke, MD (Panelist)
Hope S. Rugo, MD (Panelist)
Charlotte Kuperwasser, PhD (Panelist)
Comments by: Larry Norton, MD (Moderator)

Inhibiting the growth of cancer cells
Response by:
Marc E. Lippman, MD (from the audience)
Kathleen & Stanley Glaser Professor; Chairman, Department of Medicine Miller School of Medicine, University of Miami, Miami, FL
James N. Ingle, MD (from the audience)
Head, Breast Cancer Research Program, Mayo Clinic Cancer Center Foust Professor of Oncology, Mayo Medical School Rochester, MN
Introduction by: Larry Norton, MD (Moderator)

Behavior of cancer cells within their environment
Response by:
Charlotte Kuperwasser, PhD (Panelist)
Comments by: Larry Norton, MD (Moderator)

Why some organs are more susceptible to cancer
Response by:
Robert A. Weinberg, PhD (Panelist)
Michael F. Clarke, MD (Panelist)
Hope S. Rugo, MD (Panelist)
Comments by: Larry Norton, MD (Moderator)

Stem cell behavior and Platelets (aids in blood clotting)
Response by:
Joan S. Brugge, PhD (Panelist)
Introduction by: Larry Norton, MD (Moderator)


Closing Remarks:

Evelyn H. Lauder
Founder and Chairman, The Breast Cancer Research Foundation