Antonio C. Wolff, MD
Professor of Oncology
Breast Cancer Program
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University
In early April 2012, Dr. Wolff was named an Associate Editor of the Journal of Clinical Oncology. He joins BCRF's Chairman of the Scientific Advisory Committee, Dr. Clifford Hudis and fellow grantees, Drs. Pamela Goodwin and Bruce Haffty, who are also current Associate Editors. Read more...
2013-2014 BCRF Project:
On behalf of the Translational Breast Cancer Research Consortium (TBCRC)
The Translational Breast Cancer Research Consortium (www.tbcrc.org) united the efforts of many leading breast cancer programs from top academic medical centers throughout the United States. The Consortium, led by laboratory scientists and clinical researchers, pursues focused clinical trials that integrate clinical and laboratory studies in an effort to accelerate progress in breast cancer clinical research. Since its inception in late 2005, 28 clinical trials have been approved, 19 of which have been completed/closed to accrual.
Results from the first nine completed TBCRC trials – two in triple negative breast cancer, two in HER2 positive disease, two in hormone receptor (HR) negative breast cancer (one of which was HR negative/ androgen receptor positive), one in HER2 negative breast cancer, one that examined optimal ways to use blood tests to follow patients receiving treatment for advanced breast cancer, and one that examined the role of magnetic resonance imaging (MRI) to help identify patients most likely to respond to systemic therapies before surgery – have been presented at national meetings. Three of them have since been published in peer-reviewed journals, like the Journal of Clinical Oncology (TBCRC 001 Carey and 006 Chang) and Cancer (TBCRC 017 De Los Santos). Results from four other recently completed studies (two in triple negative breast cancer, one in endocrine resistant women, and one that assessed the prognostic impact of a biomarker in patients presenting with stage IV breast cancer) were presented at the June 2013 American Society of Clinical Oncology (ASCO) Annual Meeting.
The TBCRC trials have provided critical insight in the quest to develop more effective and individualized therapies for the various subtypes of breast cancer.
Dr. Wolff received his medical degree from the Universidade Federal do Rio de Janeiro (Brazil, 1986). He completed an Internal Medicine residency at the Mount Sinai Medical Center (New York, 1991) and Medical Oncology fellowship at Johns Hopkins (Baltimore, 1995). He is a Professor of Oncology and member of the Breast Cancer Research Program at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. His research interests include new treatment strategies and the development of prognostic and predictive biomarkers (tissue, blood, and imaging).
Dr. Wolff is a member of the Breast Cancer Committee of the Eastern Cooperative Oncology Group (ECOG) and the Breast Cancer Guidelines Committee of the National Comprehensive Cancer Network (NCCN). He is past Chair of the Health Services Committee of the American Society of Clinical Oncology (ASCO), which is the committee that oversees ASCO's efforts in the development, dissemination, and implementation of practice guidelines. He is also a member of ASCO's new Quality Care Committee, and is also interested in survivorship, needs assessments, and educational needs of breast cancer patients
Dr. Wolff is the Executive Officer for the Translational Breast Cancer Research Consortium. He maintains an active clinical practice at Johns Hopkins dedicated to the care of patients with breast cancer. In 2009, he received a Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute.