Rachel Schiff, PhD
Department of Medicine, Breast Center
Baylor College of Medicine
2013-2014 BCRF Project:
(The Macy's Award)
Co-Investigator: C. Kent Osborne, MD, Baylor College of Medicine, Houston
Effective targeted treatments against the estrogen receptor-positive (ER+) and HER2+ breast cancers are currently available in the clinic, but tumor resistance is common. The goals of Drs. Osborne and Schiff’s studies are to continue to characterize new models of resistance that will allow for genomic, molecular, and therapeutic studies aiming to identify key molecules responsible for treatment resistance and to develop new treatment strategies that will improve response and patient outcome. In 2013-2014 Drs. Schiff and Osborne will continue to identify most effective drug combinations with a focus on novel inhibitors of kinase proteins activated by growth factor signaling and new agents, called SERDS, that can degrade the ER protein They will further investigate compensatory and feedback signaling induced in tumors in response to these drugs in order to understand how to prevent the acquisition a secondary resistance. The role of a few new potential genes in resistance to antiHER2 therapies will also continue to be explored.
Dr. Schiff is Associate Professor at the Baylor College of Medicine, Sue & Lester Smith Breast Center and the Departments of Medicine and Molecular and Cellular Biology. She is an internationally recognized expert in breast cancer translational research and in preclinical therapeutic models, especially concerning endocrine, HER2, and additional targeted therapies. Dr. Schiff has received her PhD in 1992 from Hebrew University Hadassah Medical School in Jerusalem and had completed her post-doctoral fellowship at University of Texas Health Science Center, San Antonio. She joined Baylor College of Medicine in 1999 as a faculty member of the Sue & Lester Smith Breast Center.
Dr. Schiff's research focuses on understanding key signaling pathways in breast cancer and on identifying therapeutic strategies to overcome them. Major interests include molecular aspects of estrogen receptor (ER) action in breast cancer, the crosstalk between the ER signaling network and growth factor receptor and cellular kinase pathways, the role of ER co-regulators in breast cancer development and progression, mechanisms of resistance to targeted therapies, and the identification of biomarker and signatures of hormonal and antiHER2 therapy resistance for therapeutic interventions. Dr. Schiff's research is partly supported by grants from the National Cancer Institute, BCRF, Susan G. Komen for the Cure, and the Department of Defense Breast Cancer Research Program.