Michael F. Press, MD, PhD
Harold E. Lee Chair in Cancer Research
Norris Comprehensive Cancer Center
University of Southern California
Los Angeles, California
2013-2014 BCRF Project:
(The Bloomingdale's Award)
Estrogen receptor (ER) protein in breast cancer cell nuclei has been a useful therapeutic target for treatment of breast cancer patients since the 1980s. Estrogen receptor in tumor cell nuclei facilitates responsiveness to circulating estrogen hormones in both normal tissues and in breast cancer cells. Approximately 70% of breast cancers have ER protein expressed, and these cancers respond to estrogens with stimulation of tumor cell division. An established treatment for ER-positive breast cancers is treatment with hormone-like inhibitors of ER action to inhibit tumor cell growth or reduction of estrogen levels in post-menopausal women through inhibition with aromatase inhibitors. Because ER is such an important growth regulator of breast cancer cells there has been a largely unproductive search for mutations in the gene that encodes ER, known as ESR1.
Gene amplification is a type of genetic alteration in which a region of a chromosome containing one or more genes is duplicated, usually in tandem, many times over so the genes in this region of the chromosome are represented not by a single copy of the gene on that chromosome but by many copies of the gene. This duplication or amplification of a gene would facilitate the production of large quantities of the protein encoded by this gene. Although Dr. Press's team did not find amplification of ESR1, they have preliminarily shown that other genes, known as ER coactivators, are amplified in some breast cancers. This observation has important implications for women who have breast cancer. It suggests that ER coactivators may be present at high levels in some cancers facilitating responses by ER to lower levels of estrogen stimulation. In their preliminary investigations they have also found mutations in the genetic sequence of some of the coactivators of ER. These observations suggest a potential effect on responsiveness to anti-estrogen therapy. The goals of Dr. Press's investigations are 1) to confirm that ER coactivator genes are indeed altered, either amplified or mutated, in human breast cancers, 2) to determine if these ER alterations in cancers are more (or less) responsive to anti-estrogen therapy, and 3) to use human breast cancer cell lines to model response to endocrine therapy in cancers with and without ER coactivator gene amplification. If breast cancers with ER coactivator gene alterations were particularly responsive (or unresponsive) to hormonal treatments, this could substantially alter the need for these women to be treated with chemotherapy.
Dr. Michael F. Press is a board certified pathologist who has authored or co-authored more than 180 papers and is recognized for his work in characterizing molecular genetic alterations of breast cancer. He is a Surgical Pathologist at the USC+Los Angeles County Hospital and the USC Norris Comprehensive Cancer Center where he is a Professor of Pathology and holds the Harold E. Lee Chair in Cancer Research. He was formerly an Assistant Professor and Associate Professor of Pathology and a Surgical Pathologist at the University of Chicago (1981-1987), where he received both his medical and doctoral degrees.
Dr. Press is the director of a reference laboratory (USC Breast Cancer Analysis Laboratory) engaged in private practice pathology on a referral basis (1988-present). In this laboratory he evaluates prognostic markers and predictive markers as well as histopathology used in making treatment decisions for women with breast cancer. He is the director of the central laboratory for the Cancer International Research Group (CIRG), a clinical trials organization that evaluates new therapies in predominantly breast cancer patients but also conducts trials in several other cancers including gastric cancer.
His particular area of research interest is in molecular alterations of breast and gynecologic cancers, especially those that have the potential to be important in either diagnostic or therapeutic decision-making for patient management. The most prominent area of activity for his laboratory has been in the study of the human epidermal growth factor receptor type 2 (HER-2) in breast and other cancers. He published his first paper in this area in 1989 (Science 244: 707-712, 1989) and his laboratory is still actively contributing to this area as well as to the conduct of clinical trials evaluating HER-2 as a target for therapy.
Dr. Press is active in teaching medical students, graduate students, postdoctoral fellows and resident physicians.