C. Kent Osborne, MD
Director, Lester and Sue Smith Breast Center
Director, Dan L. Duncan Cancer Center
Professor of Medicine and Cellular and Structural Biology
Baylor College of Medicine
2013-2014 BCRF Project:
(The Macy's Award)
Co-Investigator: Rachel Schiff, PhD, Baylor College of Medicine, Houston
Effective targeted treatments against the estrogen receptor-positive (ER+) and HER2+ breast cancers are currently available in the clinic, but tumor resistance is common. The goals of Drs. Osborne and Schiff’s studies are to continue to characterize new models of resistance that will allow for genomic, molecular, and therapeutic studies aiming to identify key molecules responsible for treatment resistance and to develop new treatment strategies that will improve response and patient outcome. In 2013-2014 Drs. Schiff and Osborne will continue to identify most effective drug combinations with a focus on novel inhibitors of kinase proteins activated by growth factor signaling and new agents, called SERDS, that can degrade the ER protein (SERDs). They will further investigate compensatory and feedback signaling induced in tumors in response to these drugs in order to understand how to prevent the acquisition a secondary resistance. The role of a few new potential genes in resistance to antiHER2 therapies will also continue to be explored.
Dr. Osborne was born in St. Louis, Missouri and received his AB and his MD from the University of Missouri, both with honors. He completed his internship and residency at Johns Hopkins and followed this with three years as a Clinical Associate at the Medicine Branch of the National Cancer Institute. He was a faculty member at the University of Texas Health Science Center from 1977 until 1999 and became Chief of Medical Oncology in 1992. In 1999, Dr. Osborne moved to Baylor College of Medicine to direct a new Breast Center at Baylor College of Medicine and in 2004 he, in addition, was named Director of the Dan L. Duncan Cancer Center at Baylor.
Dr. Osborne's research interests have focused on the biology and treatment of breast cancer. He has published extensively on the role of growth factors in breast cancer pathogenesis, and he has also investigated the mechanisms of tamoxifen action and resistance in breast cancer. As previous Chairman of the Breast Cancer Committee for the Southwest Oncology Group, he directed numerous clinical trials investigating new treatment strategies in primary and metastatic breast cancer. Dr. Osborne currently directs the Baylor Breast Cancer Specialized Program of Research Excellence Grant. Dr. Osborne has authored more than 350 manuscripts dealing with the biology and treatment of breast cancer.