Gabriel N. Hortobagyi, MD, FACP
Professor and Past Chairman
Department of Breast Medical Oncology
Nellie B. Connally Chair in Breast Cancer
University of Texas MD Anderson Cancer Center
Member, BCRF Scientific Advisory Board
2013-2014 BCRF Project:
(The J.C. Penney Award)
Co-Investigator: Mien-Chie Hung, PhD, University of Texas MD Anderson Cancer Center
With BCRF support, Drs. Hortobagyi and Hung have identified three molecular targets (PKCα, MET and CDK6) and signaling pathways (mTORC/S6K1 and Gli1) that may contribute to triple negative breast (TNBC) cancer progression and may predict overall survival of patients with TNBC. In addition, using drugs that individually inhibit the three identified molecular targets, Drs. Hortobagyi and Hung found that combining any two of the three inhibitors will better inhibit cell growth of triple negative breast cancer cells than each inhibitor alone. In 2013-2014, this team will build on their findings to develop additional novel therapies for women with triple negative breast cancer.
The researchers have identified an optimal combination (combination index) and successfully examined key biological functions in cell culture systems by combinatorial therapies of kinase inhibitors. A manuscript detailing the work is ready to be submitted. Their finding will provide a means to develop effective rational combinatorial therapy of kinase inhibitors for triple negative breast cancer.
Gabriel Hortobagyi, MD, FACP is Professor of Medicine and Past Chairman of the Department of Breast Medical Oncology and Nellie B. Connally Chair in Breast Cancer at the University of Texas MD Anderson Cancer Center. He was also the Director of the Breast Cancer Research Program at the same institution. Dr. Hortobagyi has over 750 full-length publications in peer-reviewed journals; more than 350 invited papers; and over 140 book chapters to his credit.
Dr. Hortobagyi is recipient of the 1997 Brinker International Award, the 1999 Vermeille Medal of the City of Paris, France and was named Chevalier of l'Ordre de la Légion d'Honneur de France in 2001. Dr. Hortobagyi received the Glen Robbins Award in Breast Cancer Research from the New York Cancer Society and the Metropolitan Breast Cancer Group in April 2003, the Bristol-Myers Squibb 2003 Horizon Scientific Award; in 2004 Dr. Hortobagyi was the Jeffrey A. Gottlieb Memorial Award recipient, and was honored as the first recipient of the Umberto Veronesi Award for the Future Fight Against Breast Cancer. In 2005, Dr. Hortobagyi received the medal of the Mexican Society of Oncology, and the Mario Rabinovich Prize in Argentina; in 2006, he received the Luigi Castagnetta Prize in Italy, and the Pathfinder Award of the American Society of Breast Disease. In 2007, he received the Beacon Award from Cancer Care in New York, the Cruz Civica Jorge Bejarano, in Colombia, and the keys to the City of Cartagena (Colombia). In 2007, Dr. Hortobagyi was the recipient of the Gold Medal for Contributions to Translational Research in Oncology, at the First International Conference "Translational Research in Oncology" in Forli, Italy, and in 2009, he was given the ASCO Statesman Award, the Charles A. LeMaistre Outstanding Achievement Award in Cancer and the John Mendelsohn Lifetime Scientific Achievement Award. He has also received three honorary doctorates: from the Universitá degli Studi di Modena E Reggio Emilia, Modena, Italy; from the La Universidad Autonoma de Nuevo Leon, Monterrey, México; and from the Universidad de Buenos Aires, Argentina.
Dr. Hortobagyi's professional society activities include membership in the American Society of Clinical Oncology, where he has served on various task forces, chaired committees, served on the Board of Directors, and in 2005 was elected President for the term 2006-2007. He chairs the Data and Safety Monitoring Committee of the National Surgical Adjuvant Breast and Bowel Project; and served as President of the International Society of Senology. He served as a member of the U.S. National Committee for the International Union Against Cancer, the National Cancer Institute's Breast Cancer Progress Review Group, co-chaired the Operational Efficiency Working Group, and chaired the Steering Committee of the Breast Health Global Initiative and the Health Advisory Board of the Susan G. Komen Breast Cancer Foundation, and was a member of the Integration Panel of the Breast Cancer Research Program of the Department of Defense. Dr. Hortobagyi is on the Scientific Advisory Board of The Breast Cancer Research Foundation and currently chairs SWOG's Breast Committee.